Other circumstances can be even more drastically damaging to the relationship and it can happen much faster. When one or both partners are evasive or dishonest there is little chance for true communication. Avoiding telling your partner the truth, or the whole truth can result in a complete disrespect for the sanctity of the relationship.
That alone can cause enough hurt that some people are not able to forgive or trust again. When that happens the relationship is all but over.